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Cigarette smoking for weight loss By reducing the appetite and raising the metabolism , a certain number of smokers may lose weight as a consequence. Nicotine also promotes cancer growth by stimulating angiogenesis and neovascularization. In cancer cells, nicotine promotes the epithelial—mesenchymal transition which makes the cancer cells more resistant to drugs that treat cancer. Nicotine also has been shown to have significant deleterious effects on brain development, including alterations in brain metabolism and neurotransmitter systems and abnormal brain development. Gateway drug theory In animals, it is relatively simple to determine if consumption of a certain drug increases the later attraction of another drug. In humans, where such direct experiments are not possible, longitudinal studies can show if the probability of a substance use is related to the earlier use of other substances.
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